Why the study?
Does a history of Kawasaki disease increase the long-term risk of adverse cardiovascular events in survivors?
Population
2,764 patients from the Kaiser Permanente Northern California population, including 546 patients with a…
Comparison
History of Kawasaki disease vs Matched patients without a history of Kawasaki…
Design
Cohort
Follow-up
average 14.9 years
Key result
A history of Kawasaki disease was associated with a low rate of adverse cardiovascular events through age 21, with no significant difference compared to matched controls (HR 0.81; 95% CI 0.16-4.0).
Authors
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Supports standard surveillance for Kawasaki survivors to age 21; leaves open need for longer-term studies in aneurysm subgroups.
Cohort (n=2,764)
Does a history of Kawasaki disease increase the long-term risk of adverse cardiovascular events in survivors?
Effect estimate: HR 0.81 (95% CI 0.16-4.0)
Absolute Event Rate: 0.246% vs 0.217%
Survivors of Kawasaki disease have a low rate of long-term adverse cardiovascular events through age 21 that is comparable to matched controls, although those with persistent coronary aneurysms remain at higher risk.
Holve et al. (2014) conducted a cohort in Kawasaki disease (n=2,764). History of Kawasaki disease vs. Matched patients without Kawasaki disease was evaluated on Adverse cardiac events occurring at age ≥15 years (HR 0.81, 95% CI 0.16-4.0). A history of Kawasaki disease was associated with a low rate of adverse cardiovascular events through age 21, with no significant difference compared to matched controls (HR 0.81; 95% CI 0.16-4.0).