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Five tables suggest maintenance dosage intervals for common drugs used in patients with renal insufficiency, based on data in the literature. If information about a particular drug is unavailable, emphasis is given to biological half-life, normal pharmacology, and creatinine clearance for modification of the usual dose schedules. Nephrotoxicity or adverse effects in patients with renal disease are noted and adjustments for concurrent dialysis suggested. (JAMA230:1544-1553, 1974)
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William M. Bennett (1974) studied this question.
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