Key result
Aortic valve replacement is recommended for symptomatic patients and asymptomatic patients with left ventricular dysfunction, while long-term vasodilator use requires further clinical trials.
Aortic valve replacement is indicated for symptomatic chronic aortic regurgitation or asymptomatic cases with LV dysfunction, whereas routine long-term vasodilator use requires further evidence from clinical trials.
May inform aortic valve replacement timing in aortic regurgitation; leaves long-term vasodilator role open for trials.
Symptomatic patients with chronic aortic regurgitation should undergo aortic valve replacement. Asymptomatic patients with normal left ventricular function are not surgical candidates, but aortic valve replacement should be performed in most patients with left ventricular dysfunction, even if symptoms are not yet present. The short-term administration of vasodilators is generally beneficial, but there is only meager evidence that the hemodynamic benefits are maintained; for this reason, the wide application of these agents should be postponed until well-designed clinical trials document a long-term benefit.
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Peter K. Hoshino (1986) conducted a review in Chronic Aortic Regurgitation. Aortic valve replacement and vasodilators was evaluated. Aortic valve replacement is recommended for symptomatic patients and asymptomatic patients with left ventricular dysfunction, while long-term vasodilator use requires further clinical trials.
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