Key result
Classes II and III diastolic dysfunction linked to markedly higher CV hospitalization and mortality risk.
Why the study?
The study evaluated the early to late mitral filling velocity ratio (E/A) as a prognostic factor for cardiovascular hospitalizations and mortality in primary care, alongside associated nursing diagnoses.
Does the E/A ratio predict hospitalizations due to cardiovascular causes and mortality in primary care individuals?
Cohort (n=633)
Does the E/A ratio predict hospitalizations due to cardiovascular causes and mortality in primary care individuals?
Answers are grounded in this paper and cite their sources.
The E/A ratio is a significant prognostic factor for cardiovascular hospitalizations and mortality in primary care, highlighting the importance of identifying subclinical heart failure.
OBJECTIVES: To evaluate the ratio between early and late mitral filling velocities (E/A) as a prognostic factor for hospitalizations due to cardiovascular causes and mortality in primary care; to identify the main NANDA-I nursing diagnoses, interventions, and outcomes associated with diastolic dysfunction. METHOD: 633 individuals were recruited for evaluation of the E/A ratio and characterization of diastolic dysfunction. Multivariate Cox regression with Schoenfeld residual analysis, survival analysis, and hazard ratio estimation were performed. RESULTS: After six years, crude hazard ratios of 3.47, 3.60, 3.02, and 0.41 were identified for classes II and III diastolic dysfunction at cut-off points 1 and 2, respectively (p<0.01). Nursing diagnoses of Activity Intolerance, Anxiety, Fatigue, and Deficient Knowledge should be prioritized. CONCLUSION: The E/A ratio showed an altered pattern in most participants without a diagnosis of heart failure, which may indicate a subclinical form of the condition.
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Leite et al. (2025) conducted a cohort in Diastolic dysfunction (n=633). E/A ratio (early and late mitral filling velocities) was evaluated on Hospitalizations due to cardiovascular causes and mortality (HR 3.47, 3.60, 3.02, and 0.41, p=<0.01). Classes II and III diastolic dysfunction based on E/A ratio were associated with cardiovascular hospitalization and mortality over 6 years (HRs 3.47, 3.60, 3.02, and 0.41; p<0.01).
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