Key result
Prior COVID-19 links to decreased LV mass index and diastolic filling in healthy subjects.
Why the study?
Associations of IgG-SARS-positive status with cardiac function and hematological and biochemical parameters in apparently healthy subjects were poorly understood.
Does prior COVID-19 infection alter cardiac function and biomarkers of oxygen transport, blood coagulation, and inflammation in apparently healthy subjects?
Cross-Sectional (n=307)
Does prior COVID-19 infection alter cardiac function and biomarkers of oxygen transport, blood coagulation, and inflammation in apparently healthy subjects?
Answers are grounded in this paper and cite their sources.
Prior COVID-19 infection in apparently healthy subjects is associated with subclinical alterations in left ventricular filling, inflammation, blood coagulation, and hemoglobin levels.
Background: The manifestations, severity, and mortality of COVID-19 are considered to be associated with the changes in various hematological parameters and in immunity. Associations of immunoglobulin G antibodies against severe acute respiratory syndrome-linked coronavirus (IgG-SARS)-positive status with cardiac function and hematological and biochemical parameters in apparently health subjects are poorly understood. Methods: The present cross-sectional study included 307 healthy volunteers (24–69 years of age; 44.8 ± 8.6 years; 80.4% men) and was initiated in 2019 before the COVID-19 pandemic. COVID-19 episodes were confirmed by detection of IgG-SARS against SARS-CoV-2 S1 RBD to reveal 70 IgG-SARS-positive and 237 negative participants. Numerous ultrasound characteristics were assessed by echocardiography, and 15 hematological and biochemical parameters were assayed in the blood. Descriptive and comparative analysis was based on the IgG-SARS status of the participants. Results: The left ventricular mass index, mitral ratio of peak early to late diastolic filling velocity or flow velocity across the mitral valve, and deceleration time of early mitral inflow were decreased (p < 0.05) in IgG-SARS-positive participants versus those in IgG-SARS-negative participants according to multivariate logistic regression analysis. Erythrocyte sedimentation rate and platelet count were slightly increased, and blood hemoglobin was decreased in IgG-SARS-positive participants compared with those in IgG-SARS-negative participants. Conclusions: LV filling, inflammation, blood coagulation, and hemoglobin appear to be influenced by COVID-19 infection in healthy participants. Our observations contribute to the definition of vulnerabilities in the apparently healthy subjects with long COVID-19. These vulnerabilities may be more severe in patients with certain chronic diseases.
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Gumanova et al. (2023) conducted a cross-sectional in Healthy subjects with or without prior COVID-19 infection (n=307). IgG-SARS-positive status (prior COVID-19 infection) vs. IgG-SARS-negative status was evaluated on Left ventricular mass index, mitral ratio of peak early to late diastolic filling velocity, and deceleration time of early mitral inflow (p=<0.05). Prior COVID-19 infection in healthy subjects was associated with decreased left ventricular mass index and diastolic filling parameters (p < 0.05), alongside altered inflammation and coagulation.
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