Key result
Triple-drug regimen linked to ~39% higher absolute 1-month reversion to sinus rhythm vs non-triple therapy.
Why the study?
Treating recurrent atrial arrhythmias after persistent atrial fibrillation ablation is often challenging, and the effectiveness of different oral antiarrhythmic drug combinations for restoring sinus rhythm required evaluation.
Does a triple antiarrhythmic drug strategy improve the rate of reversion to sinus rhythm in patients with recurrent atrial arrhythmias after persistent atrial fibrillation ablation?
Observational (n=45)
No
Does a triple antiarrhythmic drug strategy improve the rate of reversion to sinus rhythm in patients with recurrent atrial arrhythmias after persistent atrial fibrillation ablation?
A triple antiarrhythmic drug strategy including digoxin, amiodarone or propafenone, and a beta-blocker significantly improves short-term reversion to sinus rhythm in patients with recurrent arrhythmias post-PeAF ablation.
May warrant caution in post-ablation care; leaves open benefit of triple-drug regimens pending randomized trials.
BACKGROUND AND OBJECTIVE: Treating recurrent atrial arrhythmias after persistent atrial fibrillation (PeAF) ablation is often challenging. This single-center, prospective study aimed to observe the effectiveness of different combinations of oral antiarrhythmic drugs (AADs) in reverting to sinus rhythm (SR) in patients with recurrent atrial arrhythmias after PeAF ablation. METHODS: Forty-five patients who experienced recurrent atrial arrhythmias after PeAF ablation were included. Based on their medication regimens, patients were divided into two groups, with the study group being a triple-drug group (digoxin combined with amiodarone/ propafenone and β-blocker), and the control group being a non-triple-drug group. RESULTS: The rate of reversion to SR was significantly higher in the study group (n = 29) than in the control group (n = 16) at 3 weeks (34.48% vs. 0%, p < 0.01) and 1 month (44.84% vs. 6.25%, p = 0.02) after initiating AADs. No patients with asymptomatic bradycardia were observed in either group. CONCLUSIONS: For patients with recurrent atrial arrhythmias after PeAF ablation, a regimen of low-dose digoxin combined with amiodarone/propafenone and β-blocker may effectively improve short-term reversion rates.
No takes yet. Share an insight, caveat, or question.
Jin et al. (2024) conducted an observational in Recurrent atrial arrhythmias after persistent atrial fibrillation ablation (n=45). Triple-drug regimen (digoxin, amiodarone/propafenone, and β-blocker) vs. Non-triple-drug regimen was evaluated on Reversion to sinus rhythm at 1 month (p=0.02). A triple-drug regimen of digoxin, amiodarone/propafenone, and a β-blocker improved the 1-month reversion rate to sinus rhythm compared to a non-triple regimen (44.84% vs 6.25%, p=0.02).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: