Why the study?
Does oral phytonadione correct excessive anticoagulation as effectively and safely as intravenous phytonadione in patients without major bleeding?
Population
61 consecutive patients presenting with excessive anticoagulation without major bleeding.
Comparison
Oral phytonadione vs Intravenous phytonadione
Design
RCT, Randomized
Follow-up
24 hours
Key result
Oral phytonadione achieved similar mean INR values at 24 hours compared to intravenous administration (2.6 vs 2.9) for excessive anticoagulation, despite a slower initial response.
Authors
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Supports oral phytonadione as alternative to IV for excessive anticoagulation without bleeding; confirms similar 24-hour INR correction in RCT.
RCT (n=61)
randomized
Does oral phytonadione correct excessive anticoagulation as effectively and safely as intravenous phytonadione in patients without major bleeding?
Absolute Event Rate: 34.8% vs 66.7%
Oral phytonadione is an effective and safe alternative to intravenous administration for correcting excessive anticoagulation without bleeding, achieving similar INR levels at 24 hours with potentially less overcorrection.
Lubetsky et al. (2003) conducted an RCT in Excessive anticoagulation without bleeding (n=61). Oral phytonadione vs. Intravenous phytonadione (0.5 mg or 1 mg) was evaluated on Proportion of patients achieving therapeutic range (INR 2-4) at 12 hours (baseline INR 6-10). Oral phytonadione achieved similar mean INR values at 24 hours compared to intravenous administration (2.6 vs 2.9) for excessive anticoagulation, despite a slower initial response.