Women with previous preeclampsia who developed recurrent preeclampsia had lower stroke volume (63 vs 70 mL) and higher E/E' ratio (11.02 vs 9.03) before their second pregnancy (P<0.05).
Case-Control (n=222)
Does echocardiographic assessment of maternal cardiac dysfunction identify patients at risk for recurrent preeclampsia?
Echocardiographic signs of diastolic dysfunction and altered left ventricular characteristics in the nonpregnant state can identify women with previous preeclampsia who are at high risk for recurrent preeclampsia in a subsequent pregnancy.
Absolute Event Rate: 63% vs 70%
p-value: p=<0.05
The purpose of our study was to assess cardiac function in nonpregnant women with previous early preeclampsia before a second pregnancy to highlight the cardiovascular pattern, which may take a risk for recurrent preeclampsia. Seventy-five normotensive patients with previous preeclampsia and 147 controls with a previous uneventful pregnancy were enrolled in a case-control study and submitted to echocardiographic examination in the nonpregnant state 12 to 18 months after the first delivery. All patients included in the study had pregnancy within 24 months from the echocardiographic examination and were followed until term. Twenty-two (29%) of the 75 patients developed recurrent preeclampsia. In the nonpregnant state, patients with recurrent preeclampsia compared with controls and nonrecurrent preeclampsia had lower stroke volume (63 ± 14 mL versus 73 ± 12 mL and 70 ± 11 mL, P<0.05), cardiac output (4.6 ± 1.2 L versus 5.3 ± 0.9 L and 5.2 ± 1.0 L, P<0.05), higher E/E' ratio (11.02 ± 3.43 versus 7.34 ± 2.11 versus 9.03 ± 3.43, P<0.05), and higher total vascular resistance (1638 ± 261 dyne · s(-1) · cm(-5) versus 1341 ± 270 dyne · s(-1) · cm(-5) and 1383 ± 261 dyne · s(-1) · cm(-5), P<0.05). Left ventricular mass index was higher in both recurrent and nonrecurrent preeclampsia compared with controls (30.0 ± 6.3 g/m(2.7) and 30.4 ± 6.8 g/m(2.7) versus 24.8 ± 5.0 g/m(2.7), P<0.05). Signs of diastolic dysfunction and different left ventricular characteristics are present in the nonpregnant state before a second pregnancy with recurrent preeclampsia. Previous preeclamptic patients with nonrecurrent preeclampsia show left ventricular structural and functional features intermediate with respect to controls and recurrent preeclampsia.
Valensise et al. (Tue,) conducted a case-control in Previous preeclampsia (n=222). Previous preeclampsia vs. Previous uneventful pregnancy was evaluated on Stroke volume (recurrent preeclampsia vs nonrecurrent preeclampsia) (p=<0.05). Women with previous preeclampsia who developed recurrent preeclampsia had lower stroke volume (63 vs 70 mL) and higher E/E' ratio (11.02 vs 9.03) before their second pregnancy (P<0.05).