Key result
This review explores the epidemiology, heritability, and allelic architecture of sudden cardiac death, detailing the genetics of inherited electrophysiological and structural heart diseases.
This review summarizes the genetic contributions to sudden cardiac death, highlighting the role of inherited electrophysiological and structural heart diseases in risk prediction and prevention.
May inform genetic screening in SCD families; leaves open prospective validation of risk alleles before practice change.
S udden cardiac death (SCD) is the final common end point of multiple disease processes. It results from a complex interplay of structural, metabolic, and genetic determinants. Although epidemiological risk factors such as age, prior myocardial infarction, and low ejection fraction are well established, this syndrome also has a strong genetic component. An understanding of the genetic contributions to risk could add substantially to the prediction and prevention of SCD. In this review, we explore the epidemiology, heritability, and allelic architecture of SCD and provide a detailed overview of the genetics of inherited electrophysiological and structural heart diseases that are potent risk factors for SCD.
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Noseworthy et al. (2008) conducted a review in Sudden cardiac death. This review explores the epidemiology, heritability, and allelic architecture of sudden cardiac death, detailing the genetics of inherited electrophysiological and structural heart diseases.
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