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May 18, 2026Journal of Theoretical Biology0 citationsOpen Access

A Theoretical Model for the Influence of Age, Race and Ethnicity on Retinal Mitochondria Dysfunction

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RSRiccardo SaccoKWKeren WoodGGGiovanna Guidoboni

Key Points

  • To create a theoretical model examining how age, race, and ethnicity influence retinal mitochondria dysfunction and its relation to glaucoma.
  • Developed a theoretical model integrating age, race, and ethnicity factors.
  • Analyzed clinical data on glaucoma prevalence and severity across different demographic groups.
  • Model indicates a maximum decrease in mitochondrial function by 37.84% for AA subjects and 32.4% for WE subjects.
  • Findings align with clinical observations of higher glaucoma prevalence in older individuals.
  • Suggests metabolic vulnerability contributes to glaucoma as a multifactorial disease.

Abstract

decreases with A, with a maximum decrease of 37.84 % and 32.4% for AA and WE subjects, respectively. Model predictions are consistent with clinical observations indicating higher glaucoma prevalence and severity in older individuals and in specific population groups, and strengthen the view of glaucoma as a multifactorial neurodegenerative disease in which metabolic vulnerability may represent one contributing pathway.

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Cite This Study

Sacco et al. (2026) studied this question.

synapsesocial.com/papers/6a0aabc25ba8ef6d83b6f73chttps://doi.org/10.1016/j.jtbi.2026.112502
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