Postprandial Reactive Hypoglycemia Due to Disproportionate Insulin Secretion in Young Adult Japanese Women with a Normal Weight and a History of Childhood Obesity: A Three-case Series with a Review of Literature

Despite the increasing number of patients diagnosed with postprandial reactive hypoglycemia (PRH), standardized diagnostic criteria and evaluation methods have not been established. We report three cases of PRH in young adult Japanese women with a normal body weight, identified through oral glucose tolerance testing and continuous glucose monitoring. In these patients, PRH was likely driven by disproportionately increased insulin secretion, possibly related to residual insulin resistance stemming from a history of childhood obesity. As PRH can occur in individuals with various known and yet-to-be-defined predispositions, careful assessment of the underlying contributing factors is essential.