Demonstrates effective gene silencing in plants, suggesting improvements in crop genomics.
We developed an intronic artificial microRNA (IamiRNA) strategy that combines CRISPR/Cas9-mediated knock-in with endogenous miRNA processing for plant gene silencing. By inserting amiRNA precursors into introns of endogenous genes, this approach enables effective and tissue-specific gene silencing without persistent transgene expression, offering a promising tool for functional genomics and crop improvement.
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Dong et al. (2026) studied this question.
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