Key result
NMS-associated rhabdomyolysis and contrast exposure linked to 2 months of dialysis dependence for severe AKI.
Why the study?
Neuroleptic malignant syndrome can be complicated by rhabdomyolysis and acute kidney injury that usually resolves rapidly, but some cases require hemodialysis.
Case Report (n=1)
NMS-associated rhabdomyolysis-induced AKI can require prolonged hemodialysis, especially when compounded by other renal insults like sepsis and contrast exposure.
May warrant extended monitoring for renal recovery in NMS rhabdomyolysis; leaves open the contribution of sepsis and contrast exposure.
Neuroleptic malignant syndrome (NMS) can be complicated by rhabdomyolysis, a known cause of acute kidney injury (AKI) that typically resolves within a short period. However, some cases of NMS-associated rhabdomyolysis require hemodialysis. We report a woman in her fifties who developed AKI secondary to NMS-associated rhabdomyolysis and required prolonged renal replacement therapy (RRT). She experienced sepsis and contrast exposure, and dialysis independence was achieved only after 2 months, the longest reported duration. This case highlights that NMS-associated rhabdomyolysis-induced AKI may lead to prolonged dialysis, particularly in the presence of additional risk factors for renal injury.
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Nakata et al. (2026) conducted a case report in Neuroleptic malignant syndrome-associated rhabdomyolysis with acute kidney injury (n=1). Renal replacement therapy (hemodialysis) was evaluated on Dialysis independence.
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