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May 18, 2026Biomacromolecules

pH-Responsive Glycosylated PC Nanoparticles for Oral Insulin Delivery

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Authors

XYXiaodie YuanSNShulan NiXZXingjie Zan

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Overview

Randomized trial evaluates oral insulin delivery efficacy in type 1 diabetes, suggesting a novel nanoparticle approach.

Key Points

  • This research aims to develop a pH-responsive glycosylated nanoparticle system for effective oral insulin delivery.
  • Glycosylated proanthocyanidin nanoparticles were designed using ZIF-8 template for insulin encapsulation.
  • The nanoparticles were evaluated in a type 1 diabetic mouse model to assess bioavailability and therapeutic effects.
  • The nanoparticle system demonstrated 7.9% bioavailability of insulin when orally administered.
  • Insulin stability was preserved under acidic gastric conditions, with a controlled release at physiological pH.

Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/6a0aac6d5ba8ef6d83b6fdc0https://doi.org/10.1021/acs.biomac.5c02672
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glycosylated nanoparticles for oral insulin delivery via glucose transporter to improve intestinal absorption2026
  2. 2pH‐Responsive Sodium Alginate Micro‐Nano Hydrogels for Oral Insulin Delivery: Enhancing Therapeutic Efficacy and Reducing Hypoglycemic Risk2025 · 2 citations
  3. 3Towards oral insulin-controlled release nanomedicine: A review2025 · 1 citations
  4. 4Mesoporous Silica Nanoparticles‐Based Formulations for Enhanced Oral Delivery of Peptide Drugs: A Case Study on Insulin2026 · 2 citations
  5. 5Oral Insulin Enhanced by Dual-Ligand-Modified Nanoparticles via Trans-Golgi Network-Mediated Transport2026