Pergularia daemia is a medicinal plant that has long been used in traditional medicine to manage inflammation and related conditions. In this study, extracts of the plant were prepared and incorporated into a nanogel formulation using appropriate polymers to enhance its therapeutic efficacy. Commonly known as the “kiosk vine,” it is a perennial, hairy climber belonging to the family Asclepiadaceae. The plant is valued for its antibacterial and anti-inflammatory properties, which are attributed to the presence of various phytochemicals such as flavonoids, alkaloids, terpenoids, tannins, and steroids. The research focuses on extracting bioactive compounds using suitable solvents. These compounds are then incorporated into nanogels formed by chemically or physically crosslinked polymers. Such nanogels are three-dimensional hydrogel networks with nanoscale dimensions. They offer several advantages over conventional drug delivery systems, including tunable size, ease of preparation, swelling capacity, biocompatibility, hydrophilicity, and responsiveness to external stimuli such as temperature, pH, light, and biological signals. Keywords: Pergularia daemia, Nanogel, Anti-inflammatory, Alkaloids, Terpenoids
Shaikh et al. (Fri,) studied this question.