An Examination of Cobalt(II) Porphyrin: Electrochemical Properties, Reduction Characteristics, DFT Calculations, and Molecular Docking With α‐Glucosidase

Electrochemical studies of cobalt(II) meso ‐tetrakis(3,4,5‐trimethoxyphenyl)porphyrin [Co II (T(3,4,5‐OCH 3 )PP)] were conducted using the cyclic voltammetry technique. UV‐Vis and EPR were used to investigate the reduction properties of [Co II (T(3,4,5‐OCH 3 )PP)]. The CV data show that [Co II (T(3,4,5‐OCH 3 )PP)] is reduced to [Co I (T(3,4,5‐OCH 3 )PP)] and then reacts with dichloromethane to form [Co III (T(3,4,5‐OCH 3 )PP)]. This occurs due to electrosynthesis establishing a σ bond between the cobalt atoms and the carbon atoms in the meso position of the porphyrin. UV‐Vis analysis indicates that incorporation of diethylamine and triethylamine facilitates the formation of cobalt(III) and cobalt(I). EPR confirms that [Co II (T(3,4,5‐OCH 3 )PP)] has changed into a five‐coordinate complex. Furthermore, a computer study of the HOMO–LUMO, MEP, and molecular docking of [Co II (T(3,4,5‐OCH 3 )PP)] has also been done.