Optimizing outcomes in keratolimbal allograft for limbal stem cell deficiency

Purpose of review The present review will focus on recent advancements affecting outcomes in keratolimbal allograft (KLAL). Recent findings Recent advancements involve methodologies for donor selection, eye bank preparation of KLAL tissue, risk stratification, and immunosuppression to prevent both early and late immunologic rejection. Summary Keratolimbal allograft (KLAL) remains an essential technique for addressing severe limbal stem cell deficiency in patients without access to a suitable living donor eye (whether autologous or allogeneic). While outcomes of KLAL have traditionally lagged behind those of living-related limbal allografts, recent advancement in KLAL techniques may reduce this gap.