Genetic Resistance to Brucellosis in Cows of the Auliekolsky Breed

Introduction The fight against brucellosis is an important issue for global health and veterinary medicine. Brucellosis pathogens can affect not only dozens of animal species, but also humans [9, 16]. To combat brucellosis, it is important to study the immune status of animals [8, 13]. Currently, molecular genetic approaches are widely used in the world to study animal resistance to hereditary and infectious diseases. DNA markers of genetic resistance to common infectious diseases are being searched for [17, 18]. The system of antigens in leukocytes, called the Major Histocompatibility Complex (MHC), is responsible for protecting animals from diseases. The major histocompatibility complex (MHC) plays a crucial role in determining the body's immunological reactivity [7]. Currently, the existence of a similar system has been shown in all farm animals and poultry: cattle, horses, pigs, sheep, goats, chickens, and the association of MHC antigens with susceptibility and resistance to various diseases is being actively studied.