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May 18, 20260 citationsOpen Access

TLMM v4.8: Unified Public EEG Contact Framework for Exploratory Digital Twin Inference

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KOKoji Okino

Key Points

  • To develop a unified framework linking public resting-state EEG data to digital twin inference for exploratory analysis.
  • Utilized public EEG envelope extraction and fluctuation analysis.
  • Employed various divergence metrics for statistical evaluations.
  • Conducted computational analyses to assess runtime and memory scaling properties.
  • Demonstrated near-linear runtime scaling (O(T^0.95)) and sub-linear memory scaling (O(T^0.85)) across long recordings.
  • Introduced a proof-of-contact framework using metrics like KL divergence and Spearman correlation.
  • Provided subject-specific digital twin examples and a roadmap for exploratory inference landscapes.

Abstract

This repository presents TLMM v4. 8, a unified exploratory framework connecting public resting-state EEG data to adaptive digital twin inference through envelope-based fluctuation analysis, feasibility-oriented sensitivity mapping, uncertainty-aware inference, and streaming adaptive updates. The framework integrates: 1. Public EEG envelope extraction2. Fokker–Planck landscape estimation3. Resilience-oriented inference4. Sensitivity landscape mapping5. Subject-specific digital twin construction6. Streaming adaptive update dynamics7. Limitation and constraint characterization8. Roadmap and progress tracking9. Computational feasibility analysis A central contribution of this work is the introduction of a quantitative “proof-of-contact” framework evaluating statistical comparability between simulation-generated envelope dynamics and public EEG-derived envelopes using: - KL divergence- Jensen–Shannon divergence- Earth Mover’s Distance- Spearman correlation- Dynamic Time Warping (DTW) The framework further introduces: - exploratory feasible inference landscapes in (α, τₙ) parameter space, - adaptive forgetting dynamics, - subject-specific digital twin examples, - systematic limitation mapping, - and scalability characterization under streaming adaptive inference. Computational analyses show near-linear runtime scaling (approximately O (T⁰. 95) ) and sub-linear memory scaling (approximately O (T⁰. 85) ) across long recording durations using a streaming implementation. Importantly, this work does NOT claim: - clinical validity, - physiological equivalence, - diagnosis, - prognosis, - or therapeutic utility. All analyses, figures, and metrics are exploratory and intended solely for methodological feasibility investigation and transparent uncertainty-aware computational research. Repository contents include: - Full PDF manuscript- Figures (Fig. 1–Fig. 9) - README- Exploratory computational demo script Data sources: - OpenNEURO- PhysioNet License: Research and exploratory use only.

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Cite This Study

Koji Okino (2026) studied this question.

synapsesocial.com/papers/6a0aad145ba8ef6d83b708d7https://doi.org/10.5281/zenodo.20233974
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