Key result
Review evaluates biventricular pacing alongside emerging His bundle and left ventricular septal pacing in heart failure.
Why the study?
One third of heart failure patients do not respond to standard biventricular pacing, prompting the emergence of new resynchronization modalities like His bundle pacing and left ventricular septal pacing.
What are the benefits and limitations of BiVP, HBP, and LVSP in patients with HFrEF and electrical dyssynchrony?
What are the benefits and limitations of BiVP, HBP, and LVSP in patients with HFrEF and electrical dyssynchrony?
This review discusses the benefits and limitations of traditional biventricular pacing and emerging modalities like His bundle pacing and left ventricular septal pacing for cardiac resynchronization in heart failure.
Offers synthesis of BiVP, HBP, and LVSP options in HFrEF; leaves open head-to-head trials for optimal selection.
Achieving Cardiac resynchronization therapy (CRT) with Biventricular pacing(BiVP) pacing for patients with moderate-to-severe heart failure (HF), left ventricular (LV) systolic dysfunction and ventricular dyssynchrony is well established and is currently the standard of care. Multiple studies have demonstrated significant improvement in quality of life, functional status, and exercise capacity in patients with New York Heart Association (NYHA) class III and IV heart failure who underwent resynchronization therapy1,2. In addition, resynchronization therapy is associated with survival benefit3. However, one third of patients do not respond to BIVP. New modalities for resynchronization have emerged namely His bundle pacing (HBP) and left ventricular septal pacing (LVSP). In this paper, we will review the benefits and limitations of BiVP and also the role of new pacing modalities such as HBP and LVSP in patients with HF with reduced left ventricular ejection fraction (LVEF) and electrical dysynchrony.
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Baba et al. (2021) conducted a review in Heart failure with reduced left ventricular ejection fraction and electrical dyssynchrony. Cardiac resynchronization therapy (BiVP, HBP, LVSP) was evaluated. This review evaluates the benefits and limitations of biventricular pacing alongside emerging modalities like His bundle pacing and left ventricular septal pacing in heart failure patients.
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