Key result
Seasonal variation significantly affected QT dispersion in healthy young males, with the largest dispersion in winter (71 +/- 18 ms) and the smallest in spring (43 +/- 19 ms) (P=0.001).
Why the study?
Does season affect QT dispersion in healthy young males?
Observational (n=523)
Does season affect QT dispersion in healthy young males?
Absolute Event Rate: 71% vs 43%
p-value: p=0.001
QT dispersion exhibits significant seasonal variability in healthy young males, being highest in winter and lowest in spring, which should be accounted for in clinical evaluations.
Seasonal adjustment may be needed for QT dispersion in young males; this Level 3 cohort finding leaves open prognostic relevance.
BACKGROUND: There are few data related to the seasonal influences on the QT dispersion. METHODS: We analyzed the effects of seasons on QT dispersion in a large group of healthy young males. We studied the seasonal variability of QT dispersion in 523 healthy male subjects aged 22 +/- 4 years (ranging from 20 to 26). Four seasonal 12-lead resting electrocardiograms (ECGs) recorded at double amplitude were performed at 25 mm/s at intervals of 3 months. Subsequent ECGs were recorded within 1 hour of the reference winter recording. QT dispersion was defined as the difference between the longest and the shortest mean QT intervals. RESULTS: There was a significant seasonal variation in QT dispersion (P = 0.001), with the largest QT dispersion in winter (71 +/- 18 ms) and the smallest one in spring (43 +/- 19). CONCLUSION: There exists a significant seasonal variation in QT dispersion of healthy subjects and such variability should be taken into consideration in the evaluation process of QT dispersion.
No takes yet. Share an insight, caveat, or question.
Köse et al. (2003) conducted an observational in Healthy (n=523). Winter season vs. Spring season was evaluated on QT dispersion (p=0.001). Seasonal variation significantly affected QT dispersion in healthy young males, with the largest dispersion in winter (71 +/- 18 ms) and the smallest in spring (43 +/- 19 ms) (P=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: