What question did this study set out to answer?

To examine the mechanistic roles of glutamine-glutamate cycling and liver transaminase activity in the pathogenesis of metabolic syndrome and insulin resistance.

January 1, 2012World Journal of GastroenterologyOpen Access

Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome

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Authors

SSSilvia SookoianConsejo Nacional de Investigaciones Científicas y Técnicas

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Implication

Metabolite profiling reveals associations between amino acid pathways and insulin resistance in community cohorts, highlighting the liver's role in early metabolic syndrome.

Key Points

To examine the mechanistic roles of glutamine-glutamate cycling and liver transaminase activity in the pathogenesis of metabolic syndrome and insulin resistance.
Evaluated high-throughput liquid chromatography and mass spectrometry profiling of 45 plasma metabolites across two community-based cohorts.
Assessed correlations between circulating metabolite signatures, cardiometabolic risk factors, and markers of hepatic transamination.
Metabolic risk factors including obesity, hypertension, dyslipidemia, and insulin resistance correlated with branched-chain amino acids, hydrophobic amino acids, and nucleotide metabolites.
Insulin resistance traits were significantly associated with altered levels of glutamine, glutamate, and an abnormal glutamine-to-glutamate ratio.
Elevations in alanine and aspartate aminotransferases were linked to heightened hepatic transamination preceding the onset of overt fatty liver disease.

Cite This Study

Silvia Sookoian (2012) studied this question.

synapsesocial.com/papers/6a0ab9b67e716524c8ac997e https://doi.org/10.3748/wjg.v18.i29.3775

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Implication

Metabolite profiling reveals associations between amino acid pathways and insulin resistance in community cohorts, highlighting the liver's role in early metabolic syndrome.

Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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