Why the study?
Is HIV infection associated with increased arterial wave reflection in Rwandan women?
Population
343 Rwandan women with little exposure to antiretroviral therapy and without cardiovascular risk factors
Comparison
HIV infection vs HIV-uninfected
Design
Cross-sectional
Key result
HIV infection was not associated with increased arterial wave reflection, with HIV-infected women having a significantly lower central augmentation index than uninfected women (20.3 vs. 25.5, p=0.002).
Authors
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No link to increased wave reflection in ART-naive women without CV risks; hypothesis-generating and requires prospective confirmation.
Cross-Sectional (n=343)
Is HIV infection associated with increased arterial wave reflection in Rwandan women?
HIV infection is not associated with increased arterial wave reflection in women with little exposure to ART and without cardiovascular risk factors.
Absolute Event Rate: 20.3% vs 25.5%
p-value: p=0.002
Lazar et al. (2009) conducted a cross-sectional in HIV infection (n=343). HIV infection vs. HIV-uninfected was evaluated on Central augmentation index (C-AI) (p=0.002). HIV infection was not associated with increased arterial wave reflection, with HIV-infected women having a significantly lower central augmentation index than uninfected women (20.3 vs. 25.5, p=0.002).