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November 1, 1992The Annals of Applied Probability225 citationsOpen Access

Modelling Heterogeneity in Survival Analysis by the Compound Poisson Distribution

OAOdd O. Aalen

Key Points

  • To develop a survival analysis framework that models unobserved individual heterogeneity using a compound Poisson distribution.
  • Extended Hougaard's multiplicative heterogeneity model by modeling the random individual proportionality factor with a compound Poisson distribution.
  • Derived the mathematical properties of the distribution and fitted the model to demographic datasets on marriage rates and fertility.
  • Established a model structure that naturally incorporates a subgroup with zero susceptibility that permanently survives the risk event.
  • Demonstrated successful empirical fit to marriage rate and fertility data while retaining key theoretical and analytical properties of survival models.

Abstract

When making probabilistic models for survival times, one should consider the fact that individuals are heterogeneous. The observed changes in population intensities (or hazard rates) over time are a mixed result of two influences: on the one hand, the actual changes in the individual hazards, and, on the other hand, the selection due to high-risk individuals leaving the risk group early. I will consider the common multiplicative model for heterogeneity, but with the new feature that the random proportionality factor has a compound Poisson distribution. This distribution is studied in some detail. It is pointed out how its application to the survival situation extends a model of Hougaard, inheriting several nice properties. One important feature of the model is that it yields a subgroup of zero susceptibility, which "survives forever." This is a relevant model in medicine and demography. Two examples are given where the model is fitted to data concerning marriage rates and fertility.

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Cite This Study

Odd O. Aalen (1992) studied this question.

synapsesocial.com/papers/6a0af84653fc0b85715d0306https://doi.org/10.1214/aoap/1177005583
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