Key result
Patients with bicuspid aortic valve disease had larger ascending aortas (18.3 vs 15.2 mm/m2; P<0.001) and higher rotational flow (31.7 vs 2.9 mm2/s; P<0.001) than healthy volunteers.
Why the study?
Do 3-dimensional flow abnormalities assessed by cardiovascular MR correlate with aortic dilation in patients with bicuspid aortic valve disease?
Cross-Sectional (n=142)
Do 3-dimensional flow abnormalities assessed by cardiovascular MR correlate with aortic dilation in patients with bicuspid aortic valve disease?
Absolute Event Rate: 18.3% vs 15.2%
p-value: p=<0.001
Cardiovascular MR reveals that 3-dimensional flow abnormalities and cusp fusion type are major contributors to ascending aortic dilation in bicuspid aortic valve disease.
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Supports 4D-flow CMR in bicuspid aortic valve evaluation; leaves open causal mechanisms and need for longitudinal outcome studies.
Bissell et al. (2013) conducted a cross-sectional in Bicuspid aortic valve disease (n=142). Cardiovascular MR vs. Healthy volunteers was evaluated on Ascending aorta size (mm/m2) (p=<0.001). Patients with bicuspid aortic valve disease had larger ascending aortas (18.3 vs 15.2 mm/m2; P<0.001) and higher rotational flow (31.7 vs 2.9 mm2/s; P<0.001) than healthy volunteers.
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