Key result
Epigenetic age acceleration in adolescents is linked to increased insulin resistance at two years.
Why the study?
Is epigenetic age acceleration associated with future cardiometabolic risk indicators in adolescents?
Cohort
Is epigenetic age acceleration associated with future cardiometabolic risk indicators in adolescents?
Epigenetic age acceleration in adolescence may serve as a prospective biomarker for developing adverse cardiometabolic profiles, including insulin resistance and altered fat distribution.
BACKGROUND AND AIMS: To examine the cross-sectional relationship between dietary intake and epigenetic age acceleration, as well as the prospective relationship between epigenetic age acceleration and cardiometabolic parameters measured two years later. METHODS AND RESULTS: ), fasting insulin (β = 0.86 μIU/mL), and insulin resistance (β = 0.21). Skin-Blood acceleration was associated with decreased HDL in males, and PedBE acceleration was associated with triglycerides in both sexes, though in opposing directions. CONCLUSION: Adolescent diet was not strongly associated with baseline epigenetic age acceleration. However, epigenetic age acceleration was associated prospectively with fat distribution and insulin resistance.
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Lee et al. (2026) conducted a cohort in Cardiometabolic risk. Epigenetic age acceleration was evaluated on Cardiometabolic parameters (fasting insulin, insulin resistance, HDL, triglycerides). Epigenetic age acceleration in adolescents was prospectively associated with fat distribution, fasting insulin (β = 0.86 μIU/mL), and insulin resistance (β = 0.21) at two years.
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