What question did this study set out to answer?

To evaluate the chemopreventive effects of vitamin K2 on tumor recurrence and overall survival in patients with hepatitis C virus-related hepatocellular carcinoma following curative treatment.

March 20, 2007Journal of Gastroenterology and Hepatology

Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection

View Full Paper

Ask AI

Bookmark

Authors

SKSatoru KakizakiNational Hospital Organization Takasaki Medical Center NSNaondo SoharaSohar University KSKen SatoSapporo Medical University

Discussion

Member takes

Implication

Randomized trial demonstrates reduced recurrence with vitamin K2 in hepatitis C hepatocellular carcinoma, indicating chemopreventive value despite unchanged overall survival.

Key Points

To evaluate the chemopreventive effects of vitamin K2 on tumor recurrence and overall survival in patients with hepatitis C virus-related hepatocellular carcinoma following curative treatment.
Randomized trial of 60 patients confirmed free of hepatocellular carcinoma following surgical resection or radiofrequency ablation, allocated to oral menatetrenone (45 mg/day, n=30) or a control group (n=30).
All enrolled patients were positive for hepatitis C virus antibody and negative for hepatitis B surface antigen, with recurrence and survival tracked over a 36-month follow-up.
Cumulative recurrence-free rates were significantly higher in the vitamin K2 group compared with controls at 12 months (92.3% vs 71.7%), 24 months (48.6% vs 35.9%), and 36 months (38.8% vs 9.9%; P=0.045).
Cumulative overall survival rates did not differ significantly between the vitamin K2 and control groups at 12 months (100% vs 95.8%), 24 months (95.0% vs 90.2%), or 36 months (77.5% vs 66.4%; P=0.70).

Cite This Study

Kakizaki et al. (2007) studied this question.

synapsesocial.com/papers/6a0b5169db419d24cd5d02db https://doi.org/10.1111/j.1440-1746.2007.04844.x

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial demonstrates reduced recurrence with vitamin K2 in hepatitis C hepatocellular carcinoma, indicating chemopreventive value despite unchanged overall survival.

Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection

Discussion

Member takes

Implication

Key Points

Cite This Study

Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider