Effect of Microbial Fractions on the Metabolism of Liver and Monocytes From Mice

The complex biochemical interactions which occur between parasites and their host cells require elucidation for a clear understanding of how an infectious process develops. Whether the reactions between microorganisms and tissues occur directly or are mediated through second-ary mechanisms has been the subject of con-siderable discussion (Sanford, Barnett, and Gott, 1960; Gilbert, 1960; Atkins, 1960). The administration of bacterial products (e.g., endotoxins) generally elicits profound physio-logical changes in recipient animals, and it seems clear that many of the effects on cell metabolism are related to andrenergic mecha-nisms. Other studies (Yunis and Harrington,