SUMMARY.— The sebum excretion rate and skin surface liquid composition were determined before and after 1 and 2 months of therapy in patients taking a trimethoprim-sulphamethoxazole combination for acne vulgaris. Trimethoprim-sulphamethoxazole caused a significant reduction in skin surface free fatty acid and a significant rise in skin surface triglyceride after 1 and 2 mionths of therapy. There were no significant changes in sebum excretion rate, squalene or wax ester.
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Cotterill et al. (1971) studied this question.
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