Oxidized LDLs (oxLDLs) induce various cellular dysfunctions potentially implicated in the pathogenesis ofatherosclerosis. For instance, toxic concentrations of oxLDLs trigger ER stress, autophagy and apoptosis. High-density lipoproteins (HDLs) counteract several adverse biological effects triggered by oxLDLs. Our recent study reveals that HDLs inhibit the activation of ER stress and of autophagy induced by oxLDLs.
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Muller et al. (2011) studied this question.