Large aortic root dimension was independently associated with higher stroke volume, diastolic blood pressure, central obesity, and inflammatory markers (all P<0.01).
Cross-Sectional (n=3,160)
What are the hemodynamic and clinical correlates of abnormal aortic root dimension in adults free of coronary heart disease?
valor p: p=<0.0001
Background We evaluated the relationship of aortic root dimension (ARD) with flow output and both peripheral and central blood pressure, using multivariable equations predicting ideal sex‐specific ARD at a given age and body height. Methods and Results We measured echocardiographic diastolic ARD at the sinuses of Valsalva in 3160 adults (aged 42±16 years, 61% women) from the fourth examination of the Strong Heart Study who were free of prevalent coronary heart disease, and we compared measured data with the theoretical predicted value to calculate a z score. Central blood pressure was estimated by applanation tonometry of the radial artery in 2319 participants. ARD z scores were divided into tertiles representing small, normal, and large ARD. Participants with large ARD exhibited greater prevalence of central obesity and higher levels of inflammatory markers and lipids (0.05< P <0.0001). Stroke volume, heart rate, and both cuff and central diastolic blood pressure were progressively greater from small to large ARD (all P <0.0001). Pulse pressure was higher in small ARD ( P <0.0001). In multivariable analysis, ARD z score was related positively to stroke volume, either cuff or central diastolic blood pressure, and negatively to pulse pressure. Large ARD was also independently correlated to higher waist circumference and percentages of neutrophils and plasminogen activator inhibitor‐1 (all P <0.01). Conclusions Aortic root dilatation is associated with high diastolic blood pressure, high stroke volume, central fat distribution, and inflammatory status. In contrast, at a given diastolic blood pressure and stroke volume, aortic root dilatation is associated with lower pulse pressure and systolic blood pressure.
Simone et al. (Tue,) conducted a cross-sectional in Abnormal Aortic Root Dimension (n=3,160). Aortic root dimension (ARD) vs. Small and normal ARD was evaluated on Hemodynamic correlates including flow output and peripheral and central blood pressure (p=<0.0001). Large aortic root dimension was independently associated with higher stroke volume, diastolic blood pressure, central obesity, and inflammatory markers (all P<0.01).