Good ventriculo-arterial coupling reserve during dobutamine stress (change >0.29) was associated with significantly more favorable event-free survival in patients with dilated cardiomyopathy (P<0.001).
Cohort (n=119)
Does improvement in ventriculo-arterial coupling during dobutamine stress predict cardiovascular events in patients with dilated cardiomyopathy?
Improvement in ventriculo-arterial coupling during dobutamine stress is an independent predictor of favorable cardiovascular outcomes in patients with dilated cardiomyopathy.
p-value: p=<0.001
AIMS: The purpose of this study was to investigate the prognostic impact of the changes in ventriculo-arterial (VA) coupling during dobutamine stress on the cardiovascular events for patients with dilated cardiomyopathy (DCM). METHODS AND RESULTS: For this study, 89 DCM patients with ejection fractions of 32 ± 10% and 30 normal controls were recruited. Ees was estimated with the non-invasive single-beat method using three-dimensional echocardiography at rest and during dobutamine stress (20 μg/kg/min). Effective arterial elastance (Ea) was calculated as left ventricular (LV) end-systolic pressure divided by stroke volume, and VA coupling was calculated as Ea/Ees. Event-free survival was then tracked for 32 months. At baseline, VA coupling was far from optimal in patients with DCM compared with controls (Ea/Ees: 2.49 ± 1.02 vs. 1.04 ± 0.21, P II), and the change in VA coupling during dobutamine stress were the independent determinants of cardiovascular events (P 0.29) showed significantly favourable event-free survival than those with poor VA coupling reserve (P < 0.001). CONCLUSIONS: Improvement in VA coupling during dobutamine stress is an important determinant of cardiovascular outcome for patients with DCM.
Matsumoto et al. (Thu,) conducted a cohort in Dilated cardiomyopathy (n=119). Dobutamine stress (assessing ventriculo-arterial coupling reserve) vs. Poor ventriculo-arterial coupling reserve was evaluated on Cardiovascular events (event-free survival) (p=<0.001). Good ventriculo-arterial coupling reserve during dobutamine stress (change >0.29) was associated with significantly more favorable event-free survival in patients with dilated cardiomyopathy (P<0.001).