Angina induced by atrial pacing increased mean left ventricular end-diastolic pressure from 12 to 29 mm Hg and decreased ejection fraction from 0.47 to 0.37, reflecting increased diastolic stiffness.
Observational (n=7)
Does angina induced by atrial pacing alter left ventricular diastolic stiffness and tone?
Angina pectoris acutely and reversibly increases left ventricular diastolic stiffness, likely due to sustained contraction or impaired relaxation of the myocardium.
Absolute Event Rate: 29% vs 12%
Reported elevations of left ventricular filling pressures during angina suggest increased myocardial stiffness. Both left ventricular beginning- and end-diastolic pressures and volumes were measured in seven patients before, during, and after angina induced by atrial pacing. During nine episodes of angina, mean end-diastolic pressure rose from 12 to 29 mm Hg and ejection fraction fell from 0.47 to 0.37. Logarithms of beginning and end-diastolic pressures were plotted against the corresponding volumes for each angiogram. During angina, there was a marked increase in beginning as well as end-diastolic stiffness of the ventricle. These changes, which were reversible with resolution of angina, may be due to sustained contraction or failure of relaxation of a portion of the left ventricular myocardium during angina pectoris.
Barry et al. (1974) conducted an observational in Angina pectoris (n=7). Atrial pacing-induced angina vs. Baseline (before angina) was evaluated on Left ventricular end-diastolic pressure. Angina induced by atrial pacing increased mean left ventricular end-diastolic pressure from 12 to 29 mm Hg and decreased ejection fraction from 0.47 to 0.37, reflecting increased diastolic stiffness.