Key result
Simultaneous recording of left ventricular pressure and circumference in intact animals showed that external cardiac work is not strictly related to diastolic dimensions per Starling's law.
Population
Intact animals
Design
Preclinical
Authors
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Questions Starling's law applicability in intact hearts; leaves open contractility and distensibility roles pending human studies.
Demonstrates that changes in myocardial contractility and distensibility, rather than just diastolic dimensions, play important roles in cardiac adaptation.
Robert F. Rushmer (1956) studied Cardiovascular physiology. Spontaneous and induced cardiovascular responses was evaluated on Left ventricular pressure and circumference. Simultaneous recording of left ventricular pressure and circumference in intact animals showed that external cardiac work is not strictly related to diastolic dimensions per Starling's law.
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