In a dog with severe congestive heart failure, serum chloride concentrations (71.6-103.1 mmol/L) were inversely related to angiotensin I, aldosterone, and surrogate markers of renin activity.
Case Report (n=1)
No
Do serum chloride concentrations correlate with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure?
In a dog with severe heart failure, serum chloride concentrations were inversely correlated with RAAS activation, supporting the exploration of RAAS dysregulation as an underlying mechanism for the poor outcomes associated with hypochloremia.
A 7-year-old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin-angiotensin-aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.
Banken et al. (Thu,) conducted a case report in Severe congestive heart failure secondary to myxomatous mitral valve disease (n=1). Measurement of serum chloride and RAAS components was evaluated on Correlation of serum chloride concentrations with RAAS components. In a dog with severe congestive heart failure, serum chloride concentrations (71.6-103.1 mmol/L) were inversely related to angiotensin I, aldosterone, and surrogate markers of renin activity.