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February 1, 2019BMJ Case ReportsOpen Access

Neuroleptic malignant syndrome as part of an akinetic crisis associated with sepsis in a patient with Lewy body disease

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Population

A 65-year-old Japanese woman with Parkinson's disease, later diagnosed with Lewy body disease, presenting…

Design

Case_report

Key result

Dantrolene administration successfully treated neuroleptic malignant syndrome presenting as an akinetic crisis associated with sepsis in a patient with Lewy body disease.

Authors

SMSaki ManabeHYHidetaka YanagiHOHideki Ozawa

Discussion

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Member takes

Overview

May support dantrolene in akinetic crisis with sepsis in Lewy body disease; leaves open confirmation in prospective studies.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
A 65-year-old Japanese woman with Parkinson's disease, later diagnosed with Lewy body disease, presenting with systemic tremors, fever, and sepsis caused by pyelonephritis with acute kidney injury.
I
Intervention
Dantrolene administration
O
Outcome
Resolution of fever and improvement of symptoms

Physicians should consider neuroleptic malignant syndrome early in patients with Parkinson's disease and sepsis, even if diagnostic criteria are not fully met.

Cite This Study

Manabe et al. (2019) conducted a case report in Lewy body disease with neuroleptic malignant syndrome and sepsis (n=1). Dantrolene was evaluated on Symptom resolution. Dantrolene administration successfully treated neuroleptic malignant syndrome presenting as an akinetic crisis associated with sepsis in a patient with Lewy body disease.

synapsesocial.com/papers/6a0ba8b04f6759c6fca253d0https://doi.org/10.1136/bcr-2018-227216
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuroleptic malignant syndrome: a concealed diagnosis with multitreatment approach2019 · 8 citations
  2. 2Parkinsonism Exacerbation due to Acute Dopamine Depletion: A Conundrum Revisited2026
  3. 3THE NEUROLEPTIC MALIGNANT SYNDROME: OFTEN AN UNRECOGNIZED GERIATRIC PROBLEM1996 · 4 citations
  4. 4Neuroleptic malignant syndrome with acute renal failure associated with rhabdomyolysis: a case report2024
  5. 5Neuroleptic Malignant Syndrome-like State Following a Withdrawal of Antiparkinsonian Drugs1981 · 216 citations