Key result
A multiscale time asymmetry index applied to human heartbeat time series was highest in young subjects and decreased with aging or heart disease.
Why the study?
Does a multiscale time asymmetry index differentiate between healthy young subjects and those with aging or heart disease?
Observational
Does a multiscale time asymmetry index differentiate between healthy young subjects and those with aging or heart disease?
Loss of time irreversibility in heartbeat dynamics may serve as a novel computational marker for aging and heart disease.
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May flag aging and disease via heartbeat dynamics; leaves open prospective validation before clinical use.
Costa et al. (2005) conducted an observational in Aging and heart disease. Multiscale time asymmetry index vs. Young/healthy subjects was evaluated on Time irreversibility (multiscale time asymmetry index). A multiscale time asymmetry index applied to human heartbeat time series was highest in young subjects and decreased with aging or heart disease.
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