A higher Life's Essential 8 score and its 133-metabolite signature were associated with a lower risk of incident coronary heart disease (OR 0.61; 95% CI 0.53-0.69 for LE8 score).
Case-Control (n=1,194)
Does a higher Life's Essential 8 score and its metabolite signature associate with a lower risk of incident coronary heart disease in low-income Black and White Americans?
A metabolite signature of Life's Essential 8 is strongly associated with lower risk of incident coronary heart disease across diverse populations, mediating a large portion of the cardiovascular benefits of ideal cardiovascular health.
Effect estimate: OR 0.61 (95% CI 0.53-0.69)
Background: Life’s essential 8 (LE8) is a comprehensive construct of cardiovascular health. Yet, little is known about the LE8 score, its metabolic correlates, and their predictive implications among Black Americans and low-income individuals. Methods: In a nested case-control study of coronary heart disease (CHD) among 299 pairs of Black and 298 pairs of White low-income Americans from the Southern Community Cohort Study, we estimated LE8 score and applied untargeted plasma metabolomics and elastic net with leave-one-out cross-validation to identify metabolite signature (MetaSig) of LE8. Associations of LE8 score and MetaSig with incident CHD were examined using conditional logistic regression. The mediation effect of MetaSig on the LE8-CHD association was also examined. The external validity of MetaSig was evaluated in another nested CHD case-control study among 299 pairs of Chinese adults. Results: Higher LE8 score was associated with lower CHD risk (standardized odds ratio, 0.61 95% CI, 0.53–0.69). The MetaSig, consisting of 133 metabolites, showed significant correlation with LE8 score ( r =0.61) and inverse association with CHD (odds ratio, 0.57 0.49–0.65), robust to adjustment for LE8 score and across participants with different sociodemographic and health status (odds ratios, 0.42–0.69; all P <0.05). MetaSig mediated a large portion of the LE8-CHD association: 53% (32%–80%). Significant associations of MetaSig with LE8 score and CHD risk were found in validation cohort ( r =0.49; odds ratio, 0.57 0.46–0.69). Conclusions: Higher LE8 score and its MetaSig were associated with lower CHD risk among low-income Black and White Americans. Metabolomics may offer an objective measure of LE8 and its metabolic phenotype relevant to CHD prevention among diverse populations.
Deng et al. (Tue,) conducted a case-control in Coronary Heart Disease (n=1,194). Life's Essential 8 (LE8) score and metabolite signature was evaluated on Incident coronary heart disease (OR 0.61, 95% CI 0.53-0.69). A higher Life's Essential 8 score and its 133-metabolite signature were associated with a lower risk of incident coronary heart disease (OR 0.61; 95% CI 0.53-0.69 for LE8 score).