Key result
Diabetes linked to ~169% higher risk of sudden cardiac death in the general population.
Why the study?
Identification of SCD risk is important in the general population from a public health perspective, prompting a summary and appraisal of available prediction models.
What are the significant predictors of sudden cardiac death in the general population?
Meta-Analysis (n=149,076)
What are the significant predictors of sudden cardiac death in the general population?
Risk prediction models incorporating factors like diabetes, QRS duration, spatial QRS-T angle, and fractional shortening may help stratify sudden cardiac death risk in the general population.
Supports incorporating diabetes into sudden cardiac death risk models; extends pooled evidence on predictors in the general population.
Objective: Identification of SCD risk is important in the general population from a public health perspective. The objective is to summarize and appraise the available prediction models for the risk of SCD among the general population. Methods: Data were obtained searching six electronic databases and reporting prediction models of SCD risk in the general population. Studies with duplicate cohorts and missing information were excluded from the meta-analysis. Results: Out of 8,407 studies identified, fifteen studies were included in the systematic review, while five studies were included in the meta-analysis. The Cox proportional hazards model was used in thirteen studies (96.67%). Study locations were limited to Europe and the United States. Our pooled meta-analyses included four predictors: diabetes mellitus (ES = 2.69, 95%CI: 1.93, 3.76), QRS duration (ES = 1.16, 95%CI: 1.06, 1.26), spatial QRS-T angle (ES = 1.46, 95%CI: 1.27, 1.69) and factional shortening (ES = 1.37, 95%CI: 1.15, 1.64). Conclusion: Risk prediction model may be useful as an adjunct for risk stratification strategies for SCD in the general population. Further studies among people except for white participants and more accessible factors are necessary to explore.
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Li et al. (2024) conducted a meta-analysis in Sudden Cardiac Death (n=149,076). Diabetes mellitus vs. Without diabetes mellitus was evaluated on Sudden Cardiac Death (ES 2.69, 95% CI 1.93-3.76). Diabetes mellitus significantly increased the risk of sudden cardiac death in the general population with a pooled effect size of 2.69.
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