Key result
A genetic risk score significantly improved prediction of incident CHD beyond traditional risk factors (HR 1.20, 95% CI 1.11-1.29 in Blacks; HR 1.10, 95% CI 1.06-1.14 in Whites).
Why the study?
Does a genetic risk score plus traditional risk factors improve prediction of incident CHD compared to traditional risk factors alone in the ARIC cohort?
Population
Participants in the Atherosclerosis Risk in Communities (ARIC) cohort, US-based
Comparison
Genetic risk score based on single nucleotide… vs Traditional risk factors alone
Design
Cohort
Follow-up
median 13 years
Authors
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May support refined CHD risk stratification; leaves open need for prospective validation before clinical use.
Cohort
Does a genetic risk score plus traditional risk factors improve prediction of incident CHD compared to traditional risk factors alone in the ARIC cohort?
Effect estimate: HR 1.20 (Blacks), HR 1.10 (Whites) (95% CI 1.11-1.29 (Blacks), 1.06-1.14 (Whites))
p-value: p=<=0.02
Incorporating a genetic risk score alongside traditional risk factors improves the prediction of incident coronary heart disease.
Morrison et al. (2007) conducted a cohort in Coronary Heart Disease. Genetic risk score (GRS) plus traditional risk factors vs. Traditional risk factors alone was evaluated on Incident CHD events (HR 1.20 (Blacks), HR 1.10 (Whites), 95% CI 1.11-1.29 (Blacks), 1.06-1.14 (Whites), p=<=0.02). A genetic risk score significantly improved prediction of incident CHD beyond traditional risk factors (HR 1.20, 95% CI 1.11-1.29 in Blacks; HR 1.10, 95% CI 1.06-1.14 in Whites).
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