Prognostic Impact of Supranormal LVEF Following Mitral Valve TEER in Patients With Secondary Atrial MR

Figures

• 

  Figure 1. Distribution of Baseline LVEF All patients had left ventricular ejection fraction (LVEF) ≥50% according to the study protocol. Of them, 137 patients (26%) had LVEF ≥65%, which was assigned to supranormal LVEF (an independent variable).

• 

  Figure 2. HR of Each LVEF Subgroup for the Primary Outcome Patients were assigned to 4 subgroups according to their baseline left ventricular ejection fraction (LVEF): LVEF <55%, LVEF between 55% and 60%, LVEF between 60% and 65%, and LVEF ≥65%. The group with LVEF <55% was defined as a reference. Only the group with LVEF ≥65% had an HR above 1.00.

• 

  Figure 3. Receiver-Operating Characteristic Analysis for the 2-Year Mortality A statistical cutoff to predict the primary outcome was calculated as 65.8% of left ventricular ejection fraction (LVEF). This is a rationale why we adopted the cutoff of LVEF 65% in the present study.

• 

  Figure 4. 2-Year Cumulative Mortality Between snLVEF and nLVEF Groups Patients with baseline supranormal left ventricular ejection fraction (snLVEF) had significantly higher cumulative mortality during the 2-year observational period following the procedure. snLVEF was defined as left ventricular ejection fraction ≥65%; normal left ventricular ejection fraction (nLVEF) was defined as left ventricular ejection fraction between 50% and 65%. ∗P < 0.05 by the log-rank test.

• 

  Figure 5. Two-Year Cumulative Mortality in the Background-Matched Cohorts Patients with baseline snLVEF had significantly higher cumulative mortality during 2-year observational period following the procedure also in the background-matched cohort. snLVEF was defined as left ventricular ejection fraction ≥65%; nLVEF was defined as left ventricular ejection fraction between 50% and 65%. ∗P < 0.05 by the log-rank test. Abbreviations as in Figure 4.

• 

  Central Illustration. Impact of Supranormal Left Ventricular Ejection Fraction Following Transcatheter Edge-to-Edge Repair for Secondary Atrial Mitral Regurgitation Patients with supranormal left ventricular ejection fraction (LVEF) (LVEF ≥65%) at baseline had higher mortality than those with normal LVEF (LVEF between 50% and 64%) during 2-year observation period following transcatheter edge-to-edge repair (TEER). MR = mitral regurgitation.