Proteomic signatures of alcohol intake and association with alcohol-related cancers

Alcohol consumption is associated with increased risk of several cancers, including hepatocellular carcinoma, upper aero-digestive tract, including oesophageal, breast, and colorectal cancers. While ethanol and its metabolites are known to have genotoxic effects, the biological mechanisms linking alcohol intake to cancer development remain poorly understood. Large-scale proteomic profiling in prospective epidemiological studies offers an opportunity to investigate molecular pathways that may underlie alcohol-related carcinogenesis.