Key result
A novel noninvasive imaging modality revealed that mechanical wave-front propagation occurs about 60 ms prior to the ordinarily accepted onset time of cardiac contraction, with a speed of 3-9 m/s.
Why the study?
Can a novel noninvasive imaging modality accurately measure the propagation of mechanical wave-fronts in human myocardial tissue?
Observational
Can a novel noninvasive imaging modality accurately measure the propagation of mechanical wave-fronts in human myocardial tissue?
Answers are grounded in this paper and cite their sources.
A novel noninvasive imaging modality reveals that mechanical wave-front propagation in human myocardial tissue occurs about 60 ms earlier than previously accepted.
Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured based on the electro-magnetic phenomena. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions, the present study shows that the propagation of the mechanical wave-front occurs at the beginning of cardiac contraction sequence for the first time (about 60 ms prior to the ordinarily accepted onset time of the contraction). From the apical side of the interventricular septum, a minute velocity component with an amplitude of several tenth micrometers is generated and it propagates from the apex to the base of the posterior wall, and then from the base to the apex of the septum, with a propagation speed of 3–9 m/s. This dynamic measurement modality is also applicable to various tissues in biology.
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Kanai et al. (2011) conducted an observational in Cardiac contraction sequence. Noninvasive novel imaging modality was evaluated on Propagation of the mechanical wave-front. A novel noninvasive imaging modality revealed that mechanical wave-front propagation occurs about 60 ms prior to the ordinarily accepted onset time of cardiac contraction, with a speed of 3-9 m/s.
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