Gestational diabetes mellitus was independently associated with an increased risk of long-term cardiovascular hospitalizations (adjusted HR 2.6; 95% CI 2.3 to 3).
Cohort (n=47,909)
No
Does a diagnosis of gestational diabetes mellitus increase the risk of long-term maternal cardiovascular morbidity in women?
Gestational diabetes mellitus is an independent risk factor for long-term maternal cardiovascular morbidity, increasing the risk of cardiovascular hospitalizations more than twofold over a decade later.
Effect estimate: adjusted HR 2.6 (95% CI 2.3 to 3)
Objective To investigate whether a diagnosis of gestational diabetes mellitus (GDM) is a risk factor for subsequent long-term cardiovascular morbidity. Design A population-based study. Setting Soroka University Medical Center, a tertiary centre in the southern region of Israel. Patients A cohort of women with and without a diagnosis of GDM who delivered during the years 1988–1999 with a follow-up period until 2010. Interventions A comparison of the incidence of cardiovascular morbidity. Results Of 47 909 deliveries that met the inclusion criteria, 4928 (10.3%) occurred in patients who were diagnosed with GDM. During a follow-up period of more than 10 years, compared with women who gave birth at the same time period, after adjustment for age and ethnicity, patients with GDM had higher rates of cardiovascular morbidity including non-invasive cardiac diagnostic procedures (OR=1.8; 95% CI 1.4 to 2.2), simple cardiovascular events (OR=2.7; 95% CI 2.4 to 3.1) and total cardiovascular hospitalisations (OR=2.3; 95% CI 2.0 to 2.5). In a Cox proportional hazards model, adjusted for comorbidities such as pre-eclampsia and obesity, GDM was independently associated with cardiovascular hospitalisations (adjusted HR 2.6, 95% CI 2.3 to 3). Conclusions GDM is an independent risk factor for long-term cardiovascular morbidity in a follow-up period of more than a decade.
Kessous et al. (Sat,) conducted a cohort in Gestational diabetes mellitus (n=47,909). Gestational diabetes mellitus (GDM) vs. Women without a diagnosis of GDM was evaluated on Cardiovascular hospitalisations (adjusted HR 2.6, 95% CI 2.3 to 3). Gestational diabetes mellitus was independently associated with an increased risk of long-term cardiovascular hospitalizations (adjusted HR 2.6; 95% CI 2.3 to 3).