We Obtain A Hemodynamic Near Normalization? Clues from Three Long-Term Survivors on Epoprostenol Treatment

Pulmonary arterial hypertension is a disease with a poor prognosis characterized by right ventricular failure, due to an increase in pulmonary vascular resistance and pulmonary arterial pressure. The introduction of specific treatments in the past decade has dramatically changed the management of the disease, and the addition of parenteral prostanoids to oral therapy has shown to improve survival in responding patients, as demonstrated by the clinical cases exposed in this paper: three female patients with moderate or severe pulmonary arterial hypertension and advanced NYHA functional class at diagnosis were able to overcome a 10-year survival along with a significant improvement in clinical and hemodynamic status thanks to the introduction of intravenous epoprostenol treatment.