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Sialic acids have important biochemical functions in healthy organisms, for example, in embryogenesis, as well as in the spread of diseases like influenza. A key step in the biosynthesis of the sialic acid N-acetylneuraminic acid is the epimerization of 1 to give 2 (see scheme, UDP=uridine diphosphate). Transition-state analogues (e.g. 4) of this enzyme-catalyzed reaction were made and tested for their inhibitory action.
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Al‐Rawi et al. (2004) studied this question.
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