Part I. Of Institutions and Character: The Era of Organisational Reform: 1. A rational therapeutics 2. Memories of underdevelopment: therapeutic research in the US 1900-1935 3. Playing it safe: the federal Food, Drug and Cosmetic Act of 1938 4. War and Peace Part II. Of Statistics and Institutions, or the Triumph of Method: 5. Managing chance 6. You gotta have heart 7. Anatomy of a controversy: the University Group Diabetes Program study 8. The dreams of reason.
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Parascandola et al. (1999) studied this question.