Key result
LDL particle size, but not susceptibility of LDL to oxidation in vitro, was independently associated with carotid intima-media thickness in 148 asymptomatic FCHL family members.
Why the study?
Is LDL particle size and susceptibility to oxidation associated with carotid IMT in asymptomatic members of FCHL families?
Observational (n=148)
Is LDL particle size and susceptibility to oxidation associated with carotid IMT in asymptomatic members of FCHL families?
Small, dense LDL particles are independently associated with increased carotid IMT in asymptomatic FCHL family members, suggesting their utility as a diagnostic indicator for coronary artery disease risk.
Small dense LDL size may mark carotid atherosclerosis in FCHL families; hypothesis-generating and should not yet change practice.
Background and Purpose — In addition to low-density lipoprotein (LDL) cholesterol, small, dense LDL particles and oxidative modification of LDL have been linked to the pathogenesis of atherosclerosis. The present study was aimed at investigating the association between carotid artery intima-media thickness (IMT) and LDL particle size and susceptibility of LDL to oxidation in vitro in asymptomatic members of familial combined hyperlipidemia (FCHL) families. Methods — LDL particle size, susceptibility of LDL to oxidation in vitro, and carotid IMT were measured in 148 asymptomatic FCHL family members. Results — LDL particle size and lag time for LDL oxidation were reduced in hyperlipidemic compared with normolipidemic family members. LDL particle size, serum total cholesterol, and α-tocopherol in LDL were independently associated with lag time for LDL oxidation in multivariate analysis. LDL particle size was associated with carotid mean IMT independently of clinical, lipid, and antioxidant variables in multivariate analysis. Although the susceptibility of LDL to oxidation in vitro was correlated with mean IMT, it did not have a significant independent contribution to variation in mean IMT in the multivariate model. Conclusions — We conclude that LDL particle size but not susceptibility of LDL to oxidation in vitro is independently associated with carotid IMT in asymptomatic FCHL family members. These results imply that small, dense LDL as an inherent feature of FCHL is an important diagnostic indicator for coronary artery disease risk in FCHL.
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Liu et al. (2002) conducted an observational in Familial combined hyperlipidemia (n=148). LDL particle size and susceptibility to oxidation was evaluated on Carotid artery intima-media thickness (IMT). LDL particle size, but not susceptibility of LDL to oxidation in vitro, was independently associated with carotid intima-media thickness in 148 asymptomatic FCHL family members.
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