PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
September 13, 2017New England Journal of Medicine150 citations

Tragedy, Perseverance, and Chance — The Story of CAR-T Therapy

View Full Paper
LRLisa RosenbaumBrigham and Women's Hospital

Key Points

Key points are not available for this paper at this time.

Abstract

The FDA has approved the first chimeric antigen receptor T-cell therapy, whose emergence reflects the incremental insights of many scientists over decades. Its story says as much about the methodical nature of scientific progress as about the passions that sustain it.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Lisa Rosenbaum (2017) studied this question.

synapsesocial.com/papers/6a0cab79a36b1d7944e8aac0https://doi.org/10.1056/nejmp1711886
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Global Registration Trial of Efficacy and Safety of CTL019 in Pediatric and Young Adult Patients with Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL): Update to the Interim Analysis2017 · 63 citations
  2. 2Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor2014 · 1,616 citations
  3. 3Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia2011 · 3,573 citations
  4. 4Cancer immunotherapy: harnessing the immune system to battle cancer2015 · 1,450 citations
  5. 5T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia2011 · 2,425 citations