Background: Prior work implicated the sialic acid Neu5Gc as a xeno-autoantigen in humans. Results: Dietary Neu5Gc can be utilized by the murine gastrointestinal system and distributed for glycosylation in peripheral tissues. Conclusion: Diets containing Neu5Gc can lead to human-like tissue incorporation. Significance: Neu5Gc may be a dietary risk factor for progression of carcinomas, atherosclerosis, and immunologic diseases in humans.
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Banda et al. (2012) studied this question.
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